Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAPEPLD | Q6IQ20 | 10/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29434113 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2NAPEPLDPIK3CBPIK3CAHDAC8 | |
| SCHEMBL241043 | 0.80 | PIK3CB (0.57) | SMN1; SMN2NAPEPLDPIK3CBPIK3CAPIK3CD | |
| SCHEMBL24766039 | 0.78 | MAPT (0.47) | SMN1; SMN2NAPEPLDPIK3CBPIK3CAPIK3CD | |
| SCHEMBL29434163 | 0.77 | PTGS2 (0.47) | SMN1; SMN2NAPEPLDPIK3CBMEN1MAPT | |
| SCHEMBL24766029 | 0.77 | PTGS2 (0.47) | SMN1; SMN2NAPEPLDPIK3CBMEN1MAPT | |
| SCHEMBL24766030 | 0.76 | KMT2A (0.47) | SMN1; SMN2PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL244072 | 0.75 | PIK3CA (0.47) | SMN1; SMN2PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL25340939 | 0.75 | KMT2A (0.44) | SMN1; SMN2PIK3CBMEN1MAPTKMT2A | |
| SCHEMBL25340937 | 0.75 | KMT2A (0.44) | SMN1; SMN2PIK3CBMEN1MAPTKMT2A | |
| SCHEMBL29434078 | 0.75 | PIK3CA (0.47) | SMN1; SMN2PIK3CBPIK3CAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11407737-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2022-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11407737-B2 | Inhibitors of RAF kinases | BRAF, RAF1, ARAF | SMN1; SMN2 3700/4885NAPEPLD 4150/4885PIK3CB 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.