Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | NAPEPLD | Q6IQ20 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL241043 | 0.86 | PIK3CB (0.57) | MAPTCYP1A2CYP2D6PIK3CBTHRB | |
| SCHEMBL242170 | 0.83 | KMO (0.56) | MAPTCYP1A2CYP2D6PIK3CBTHRB | |
| SCHEMBL24766030 | 0.82 | KMT2A (0.47) | MAPTCYP1A2CYP2D6PIK3CBTHRB | |
| SCHEMBL29434180 | 0.81 | GSK3B (0.47) | MAPTCYP1A2CYP2D6PIK3CBTHRB | |
| SCHEMBL244072 | 0.81 | PIK3CA (0.47) | MAPTCYP1A2CYP2D6PIK3CBTHRB | |
| SCHEMBL29434078 | 0.81 | PIK3CA (0.47) | MAPTCYP1A2CYP2D6PIK3CBTHRB | |
| SCHEMBL2552790 | 0.78 | IRAK4 (0.58) | MAPTPIK3CBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24993366 | 0.78 | AOC3 (0.45) | MAPTCYP1A2PIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL30642987 | 0.78 | IRAK4 (0.58) | MAPTPIK3CBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24766834 | 0.78 | SMN1; SMN2 (0.43) | MAPTPIK3CBPIK3CDAKT1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340543-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2022-10-27 | — | — | US | disclosed |
| US-11407737-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2022-08-09 | — | — | US | disclosed |
| US-11407737-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2022-08-09 | — | — | US | disclosed |
| US-20220089569-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2022-03-24 | — | — | US | disclosed |
| WO-2022060996-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2022-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220340543-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, ARAF | MAPT 2859/4885CYP1A2 4302/4885CYP2D6 4339/4885 |
| US-11407737-B2 | Inhibitors of RAF kinases | BRAF, RAF1, ARAF | MAPT 2859/4885CYP1A2 4302/4885CYP2D6 4339/4885 |
| US-20220089569-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, ARAF | MAPT 2859/4885CYP1A2 4302/4885CYP2D6 4339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.