Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 10/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | CTSE | P14091 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31580329 | 0.90 | DRD2 (0.35) | EBPPRMT1HSD11B1DRD2 | |
| SCHEMBL4463284 | 0.78 | ROCK2 (0.36) | EBPROCK2KCNH2HSD11B1GBA1 | |
| SCHEMBL5072825 | 0.73 | GRM2 (0.41) | EBPROCK2KCNH2CYP11B2 | |
| SCHEMBL27151785 | 0.72 | HRH3 (0.31) | — | |
| SCHEMBL12120907 | 0.72 | CHRM2 (0.38) | PRMT1KCNH2 | |
| SCHEMBL19534289 | 0.71 | IDO1 (0.48) | EBPROCK2CTSDCTSEBACE1 | |
| Hydrochloric Acid SCHEMBL2637676 | 0.70 | CHRM2 (0.37) | PRMT1KCNH2 | |
| SCHEMBL15000803 | 0.70 | KDM4E (0.33) | EBPROCK2GBA1CYP11B2DRD2 | |
| Hydrochloric Acid SCHEMBL2637674 | 0.69 | CHRM2 (0.36) | PRMT1 | |
| SCHEMBL26668748 | 0.67 | DRD2 (0.37) | GBA1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373652-A1 | SUBSTITUTED PIPERIDINE SPIRO PYRROLIDINONE AND PIPERIDINONES USED AS H3 MODULATORS | SANOFI (FR) | 2011-10-12 | — | — | EP | claimed |
| WO-2010065803-A1 | SUBSTITUTED PIPERIDINE SPIRO PYRROLIDINONE AND PIPERIDINONES USED AS H3 MODULATORS | SANOFI-AVENTIS (FR) | 2010-06-10 | — | — | WO | claimed |
| EP-2373652-A1 | SUBSTITUTED PIPERIDINE SPIRO PYRROLIDINONE AND PIPERIDINONES USED AS H3 MODULATORS | SANOFI (FR) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010065803-A1 | SUBSTITUTED PIPERIDINE SPIRO PYRROLIDINONE AND PIPERIDINONES USED AS H3 MODULATORS | SANOFI-AVENTIS (FR) | 2010-06-10 | — | — | WO | disclosed |