Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | POLQ | O75417 | 11/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24769729 | 0.83 | SMN1; SMN2 (0.43) | POLQDHFR | |
| SCHEMBL24770364 | 0.81 | POLQ (0.44) | KCNQ3KCNQ2POLQDHFR | |
| SCHEMBL24769992 | 0.78 | POLQ (0.70) | POLQ | |
| SCHEMBL19945811 | 0.75 | MEN1 (0.47) | — | |
| SCHEMBL29479275 | 0.75 | MEN1 (0.47) | — | |
| SCHEMBL29276870 | 0.73 | POLQ (0.44) | POLQ | |
| SCHEMBL16368532 | 0.73 | HTT (0.46) | KCNQ3KCNQ2POLQPDE10A | |
| SCHEMBL31248788 | 0.73 | HTT (0.46) | KCNQ3KCNQ2POLQPDE10A | |
| SCHEMBL31541641 | 0.72 | POLQ (0.43) | POLQDHFR | |
| SCHEMBL19945742 | 0.72 | ALDH1A1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |