Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLQ | O75417 | 8/20 | 0.42 |
| ▸ | RORB | Q92753 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24769722 | 0.83 | KCNQ3 (0.43) | POLQDHFR | |
| SCHEMBL24770364 | 0.76 | POLQ (0.44) | POLQDHFR | |
| SCHEMBL31032174 | 0.76 | POLQ (0.70) | POLQ | |
| SCHEMBL16368532 | 0.76 | HTT (0.46) | SMN1; SMN2LMNAL3MBTL1POLQHTT | |
| SCHEMBL31248788 | 0.76 | HTT (0.46) | SMN1; SMN2LMNAL3MBTL1POLQHTT | |
| SCHEMBL1957953 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL31297029 | 0.75 | CLCN2 (0.47) | L3MBTL1POLQMAPTHTTALDH1A1 | |
| SCHEMBL30858965 | 0.74 | POLB (0.49) | L3MBTL1POLQALDH1A1RAB9A | |
| SCHEMBL14610550 | 0.74 | HDAC4 (0.60) | LMNAL3MBTL1MAPTHTTALDH1A1 | |
| SCHEMBL14003500 | 0.74 | MAPT (0.57) | SMN1; SMN2LMNAL3MBTL1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |