Sugi Predict

Sugi Predict / Compounds / SCHEMBL24770451

SCHEMBL24770451

SCHEMBL24770451

O=C(Nc1ccccc1)c1nonc1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HIF1A Q16665 3/20 0.53
▸ SMN1; SMN2 Q16637 3/20 0.53
▸ POLB P06746 1/20 0.50
▸ KDM4E B2RXH2 2/20 0.49
▸ ATR Q13535 1/20 0.47
▸ NPC1 O15118 2/20 0.46
▸ MEN1 O00255 1/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ HPGD P15428 1/20 0.46
▸ CYP2C19 P33261 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ ALDH1A1 P00352 2/20 0.46
▸ CCNA2 P20248 1/20 0.45
▸ CDK2 P24941 1/20 0.45
▸ FLT3 P36888 1/20 0.45
▸ CCNA1 P78396 1/20 0.45
▸ RAB9A P51151 3/20 0.45
▸ HTT P42858 1/20 0.45
▸ PTGS2 P35354 1/20 0.45
▸ ADORA3 P0DMS8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25868860 0.81 HIF1A (0.54) HIF1ASMN1; SMN2POLBKDM4EATR
SCHEMBL30999064 0.80 ALDH1A1 (0.61) HIF1AKDM4EATRKMT2AALDH1A1
SCHEMBL30999049 0.78 HIF1A (0.50) HIF1ASMN1; SMN2POLBKDM4EATR
SCHEMBL30999068 0.78 HIF1A (0.50) HIF1ASMN1; SMN2POLBKDM4EATR
SCHEMBL23989782 0.78 HIF1A (0.50) HIF1ASMN1; SMN2POLBATRNPC1
SCHEMBL24770504 0.76 SMN1; SMN2 (0.56) HIF1ASMN1; SMN2POLBATRNPC1
SCHEMBL23989961 0.76 KMT2A (0.49) HIF1ASMN1; SMN2POLBKDM4EATR
SCHEMBL30999059 0.76 HIF1A (0.49) HIF1ASMN1; SMN2POLBKDM4EATR
SCHEMBL23989805 0.76 TSHR (0.50) HIF1ASMN1; SMN2POLBATRMEN1
SCHEMBL32690991 0.76 HIF1A (0.49) HIF1ASMN1; SMN2POLBATRNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4642785-A1 IL-17A MODULATORS Usynova Pharmaceuticals Ltd. (CN) 2025-11-05 — — EP disclosed
EP-4143195-B1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2025-05-21 — — EP disclosed
US-20240376085-A1 BENZIMIDAZOLES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2024-11-14 — — US disclosed
EP-4408530-A1 BENZIMIDAZOLES AS MODULATORS OF IL-17 Janssen Pharmaceutica NV (BE) 2024-08-07 — — EP disclosed
WO-2024139171-A1 IL-17A MODULATORS USYNOVA PHARMACEUTICALS, LTD. (CN) 2024-07-04 — — WO disclosed
WO-2024138286-A1 IL-17A MODULATORS USYNOVA PHARMACEUTICALS, LTD. (CN) 2024-07-04 — — WO disclosed
US-12024524-B2 Imidazopyridazines as modulators of IL-17 JANSSEN PHARMACEUTICA NV (BE) 2024-07-02 — — US disclosed
CN-118119613-A Benzimidazoles as IL-17 modulators 詹森药业有限公司 2024-05-31 — — CN disclosed
US-20230357254-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-11-09 — — US disclosed
US-20230357254-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-11-09 — — US disclosed
US-11702422-B2 Imidazopyridazines as modulators of IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-07-18 — — US disclosed
US-11691979-B2 Imidazopyridazines as modulators of IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-07-04 — — US disclosed
US-11691979-B2 Imidazopyridazines as modulators of IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-07-04 — — US disclosed
CN-115884810-A Imidazopyridazines as IL-17 modulators 詹森药业有限公司 2023-03-31 — — CN disclosed
WO-2023049888-A1 BENZIMIDAZOLES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-03-30 — — WO disclosed
US-20230081548-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-03-16 — — US disclosed
EP-4143195-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 Janssen Pharmaceutica NV (BE) 2023-03-08 — — EP disclosed
US-20220402922-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN RESEARCH & DEVELOPMENT, LLC 2022-12-22 — — US disclosed
US-20220402922-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN RESEARCH & DEVELOPMENT, LLC 2022-12-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11691979-B2 Imidazopyridazines as modulators of IL-17 IL17A, IL23R, IL15 HIF1A 2939/4885SMN1; SMN2 3490/4885POLB 4678/4885
US-20230357254-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 IL17A, IL23R, IL15 HIF1A 2939/4885SMN1; SMN2 3490/4885POLB 4678/4885
US-12024524-B2 Imidazopyridazines as modulators of IL-17 IL17A, IL23R, IL15 HIF1A 2939/4885SMN1; SMN2 3490/4885POLB 4678/4885
US-20230081548-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 IL17A, IL23R, IL15 HIF1A 2939/4885SMN1; SMN2 3490/4885POLB 4678/4885
US-20220402922-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 IL17A, IL23R, IL15 HIF1A 2939/4885SMN1; SMN2 3490/4885POLB 4678/4885
US-11702422-B2 Imidazopyridazines as modulators of IL-17 IL17A, IL23R, IL15 HIF1A 2939/4885SMN1; SMN2 3490/4885POLB 4678/4885
US-20240376085-A1 BENZIMIDAZOLES AS MODULATORS OF IL-17 IL17A, IL23R, IL4I1 HIF1A 3870/4885SMN1; SMN2 2047/4885POLB 3776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.