Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 14/20 | 0.45 |
| ▸ | DPP4 | P27487 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24501363 | 0.89 | POLQ (0.47) | POLQKDM4E | |
| SCHEMBL24769604 | 0.89 | POLQ (0.44) | POLQDPP4 | |
| SCHEMBL30640202 | 0.88 | POLQ (0.46) | POLQ | |
| SCHEMBL31167806 | 0.86 | DPP4 (0.50) | POLQDPP4 | |
| SCHEMBL24501618 | 0.85 | POLQ (0.45) | POLQDPP4 | |
| SCHEMBL30640084 | 0.85 | POLQ (0.45) | POLQDPP4 | |
| SCHEMBL24769645 | 0.84 | POLQ (0.61) | POLQDPP4KDM4EALDH1A1NPSR1 | |
| SCHEMBL24769643 | 0.83 | PDCD1 (0.41) | POLQDPP4ALDH1A1MEN1KMT2A | |
| SCHEMBL24770297 | 0.79 | BAZ2B (0.42) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL24769173 | 0.79 | POLQ (0.75) | POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4352055-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| CN-117794927-A | O-linked thiadiazolyl compounds as inhibitors of DNA polymerase theta | 伊迪亚生物科学有限公司 | 2024-03-29 | — | — | CN | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |