Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24770186 | 0.81 | BAZ2B (0.48) | BAZ2BBAZ2ACA1CA2CA12 | |
| SCHEMBL22717325 | 0.81 | BAZ2B (0.48) | BAZ2BBAZ2ACA1CA2CA12 | |
| SCHEMBL24770927 | 0.79 | POLQ (0.45) | ALDH1A1KMT2AKDM4EMEN1NPSR1 | |
| SCHEMBL24769352 | 0.79 | BAZ2B (0.44) | BAZ2BBAZ2ACA1CA2CA12 | |
| SCHEMBL30017878 | 0.77 | BAZ2B (0.41) | BAZ2BBAZ2AMAPTALDH1A1HPGD | |
| SCHEMBL24770251 | 0.77 | BAZ2B (0.41) | BAZ2BBAZ2AMAPTALDH1A1HPGD | |
| SCHEMBL190973 | 0.76 | BAZ2B (0.51) | BAZ2BBAZ2ACA1CA2CA12 | |
| SCHEMBL29574609 | 0.76 | BAZ2B (0.51) | BAZ2BBAZ2ACA1CA2CA12 | |
| SCHEMBL3652621 | 0.76 | BAZ2B (0.51) | BAZ2BBAZ2ACA1CA2CA12 | |
| SCHEMBL16580957 | 0.74 | BAZ2B (0.49) | BAZ2BBAZ2ACA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117794927-A | O-linked thiadiazolyl compounds as inhibitors of DNA polymerase theta | 伊迪亚生物科学有限公司 | 2024-03-29 | — | — | CN | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |