Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 9/20 | 0.41 |
| ▸ | BTK | Q06187 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24773067 | 0.91 | BTK (0.49) | WEE1BTKAXLSYK | |
| SCHEMBL24773345 | 0.89 | WEE1 (0.45) | WEE1BTKEGFRJAK3AXL | |
| SCHEMBL24773141 | 0.87 | ALK (0.44) | WEE1BTKJAK3AXLSYK | |
| SCHEMBL24773152 | 0.87 | BTK (0.51) | WEE1BTKAXLSYK | |
| SCHEMBL24773062 | 0.86 | WEE1 (0.45) | WEE1BTKEGFRAXLSYK | |
| SCHEMBL24773142 | 0.84 | AXL (0.42) | WEE1BTKAXLINSRALK | |
| SCHEMBL24773115 | 0.84 | SYK (0.40) | WEE1BTKEGFRJAK3AXL | |
| SCHEMBL24773058 | 0.83 | MAPT (0.44) | BTKEGFRJAK3AXL | |
| SCHEMBL24773060 | 0.82 | BTK (0.47) | WEE1BTKAXL | |
| SCHEMBL24773877 | 0.82 | WEE1 (0.43) | WEE1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174796-A1 | PYRIMIDINE COMPOUND AS WEE-1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2022-08-25 | — | — | WO | disclosed |