Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.41 |
| ▸ | ULK1 | O75385 | 3/20 | 0.40 |
| ▸ | ULK2 | Q8IYT8 | 3/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24773067 | 0.90 | BTK (0.49) | AXLBTKSLC2A1PKMYT1TNK2 | |
| SCHEMBL24773146 | 0.88 | MAP3K14 (0.48) | AXLBTKSLC2A1MAP3K14PKMYT1 | |
| SCHEMBL24773917 | 0.88 | AXL (0.44) | AXLBTKSLC2A1MAP3K14PKMYT1 | |
| SCHEMBL24773144 | 0.87 | AXL (0.47) | AXLBTKSLC2A1MAP3K14PKMYT1 | |
| SCHEMBL24773345 | 0.87 | WEE1 (0.45) | AXLBTKSLC2A1PKMYT1WEE1 | |
| SCHEMBL24773931 | 0.86 | ULK1 (0.39) | AXLSLC2A1ULK1ULK2PKMYT1 | |
| SCHEMBL24773145 | 0.86 | AXL (0.48) | AXLBTKSLC2A1MAP3K14ULK1 | |
| SCHEMBL24773139 | 0.85 | AXL (0.46) | AXLBTKSLC2A1MAP3K14ULK1 | |
| SCHEMBL24773138 | 0.85 | AXL (0.48) | AXLBTKSLC2A1MAP3K14ULK1 | |
| SCHEMBL24773062 | 0.85 | WEE1 (0.45) | AXLBTKSLC2A1PKMYT1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174796-A1 | PYRIMIDINE COMPOUND AS WEE-1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2022-08-25 | — | — | WO | disclosed |