Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isophthalic Acid SCHEMBL8734977 | 0.97 | CYP2C9 (0.46) | CYP2C9CYP2D6HIF1AKMOMEN1 | |
| Benzoic Acid SCHEMBL1713123 | 0.90 | TSHR (0.52) | CYP2C9CYP2D6HIF1AKMT2AHPGD | |
| Benzoic Acid SCHEMBL25227095 | 0.90 | TSHR (0.52) | CYP2C9CYP2D6HIF1AKMT2AHPGD | |
| Terephthalic Acid SCHEMBL539238 | 0.90 | TSHR (0.48) | KMT2ACA12CA1CA2CA6 | |
| Terephthalic Acid SCHEMBL29389282 | 0.90 | TSHR (0.48) | KMT2ACA12CA1CA2CA6 | |
| Terephthalic Acid SCHEMBL28693414 | 0.90 | TSHR (0.48) | KMT2ACA12CA1CA2CA6 | |
| Isophthalic Acid SCHEMBL4650624 | 0.88 | HDAC3 (0.41) | CYP2C9CYP2D6HIF1AKMOMEN1 | |
| Terephthalic Acid SCHEMBL6132118 | 0.86 | TSHR (0.44) | KMT2ACA12CA1CA2CA6 | |
| Terephthalic Acid SCHEMBL599308 | 0.86 | TSHR (0.44) | KMT2ACA12CA1CA2CA6 | |
| Isophthalic Acid SCHEMBL3722557 | 0.86 | TDP1 (0.39) | CYP2C9CYP2D6HIF1AKMOMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625010-B1 | A PROCESS FOR HEAT TREATING PRESSURIZED PLASTIC CONTAINERS | PROCTER & GAMBLE (US) | 2017-08-30 | — | — | EP | claimed |
| EP-2029455-B1 | NON-ROUND PLASTIC PRESSURIZED DISPENSER | PROCTER & GAMBLE (US) | 2015-03-11 | — | — | EP | claimed |
| CN-101400734-A | Flame retardant resin composition | SABIC INNOVATIVE PLASTICS IP (NL) | 2009-04-01 | — | — | CN | claimed |
| EP-2029456-A2 | PLASTIC PRESSURIZED DISPENSER | The Procter and Gamble Company (US) | 2009-03-04 | — | — | EP | claimed |
| EP-2029455-A1 | NON-ROUND PLASTIC PRESSURIZED DISPENSER | The Procter & Gamble Company (US) | 2009-03-04 | — | — | EP | claimed |
| EP-1987100-A2 | FLAME RETARDANT RESIN COMPOSITION | Sabic Innovative Plastics IP B.V. (NL) | 2008-11-05 | — | — | EP | claimed |
| WO-2008007253-A2 | PLASTIC PRESSURIZED DISPENSER | THE PROCTER & GAMBLE COMPANY (US) | 2008-01-17 | — | — | WO | claimed |
| US-20080003387-A1 | Plastic pressurized dispenser | PROCTER & GAMBLE COMPANY, THE | 2008-01-03 | — | — | US | claimed |
| WO-2007144847-A1 | NON-ROUND PLASTIC PRESSURIZED DISPENSER | THE PROCTER & GAMBLE COMPANY (US) | 2007-12-21 | — | — | WO | claimed |
| US-20070292641-A1 | Non-round plastic pressurized dispenser | PROCTER & GAMBLE COMPANY, THE | 2007-12-20 | — | — | US | claimed |
| WO-2007097866-A2 | FLAME RETARDANT RESIN COMPOSITION | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2007-08-30 | — | — | WO | claimed |
| US-20070197696-A1 | Flame retardant resin composition | GENERAL ELECTRIC COMPANY | 2007-08-23 | — | — | US | claimed |
| EP-1625010-A1 | HEAT-TREATED PRESSURIZED PLASTIC CONTAINERS | THE PROCTER & GAMBLE COMPANY (US) | 2006-02-15 | — | — | EP | claimed |
| US-6959524-B2 | Heat-treated pressurized plastic containers and method of making | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-01 | — | — | US | claimed |
| US-20050060953-A1 | Heat-treated pressurized plastic containers | PROCTER & GAMBLE COMPANY, THE | 2005-03-24 | — | — | US | claimed |
| WO-2004106043-A1 | HEAT-TREATED PRESSURIZED PLASTIC CONTAINERS | THE PROCTER & GAMBLE COMPANY (US) | 2004-12-09 | — | — | WO | claimed |
| EP-4172268-B1 | CHEMICALLY-RESISTANT FLAME RETARDANT COMPOSITIONS | SHPP GLOBAL TECH BV (NL) | 2024-07-03 | — | — | EP | disclosed |
| US-20230323110-A1 | CHEMICALLY-RESISTANT FLAME RETARDANT COMPOSITIONS | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2023-10-12 | — | — | US | disclosed |
| EP-0803537-A2 | Impact modified polyester-polycarbonate molding compositions | GENERAL ELECTRIC COMPANY (US) | 1997-10-29 | — | — | EP | disclosed |
| EP-0787769-A2 | Impact modified polycarbonate and/or polyester compositions with high weather resistance | GENERAL ELECTRIC COMPANY (US) | 1997-08-06 | — | — | EP | disclosed |