Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ANPEP | P15144 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836673 | 0.88 | KMT2A (0.49) | ALDH1A1KMT2APKMSMN1; SMN2MEN1 | |
| SCHEMBL26756233 | 0.84 | CUL4A (0.55) | ALDH1A1KMT2APKMSMN1; SMN2MEN1 | |
| SCHEMBL30642207 | 0.84 | ANPEP (0.49) | ALDH1A1KMT2APKMSMN1; SMN2MEN1 | |
| SCHEMBL26640052 | 0.84 | ANPEP (0.49) | ALDH1A1KMT2APKMSMN1; SMN2MEN1 | |
| SCHEMBL12072639 | 0.81 | TP53 (0.36) | ALDH1A1KMT2AMEN1LMNATP53 | |
| SCHEMBL30642153 | 0.80 | ALDH1A1 (0.61) | ALDH1A1KMT2APKMSMN1; SMN2MEN1 | |
| SCHEMBL26640417 | 0.80 | ALDH1A1 (0.61) | ALDH1A1KMT2APKMSMN1; SMN2MEN1 | |
| SCHEMBL248323 | 0.77 | KMT2A (0.49) | ALDH1A1KMT2APKMSMN1; SMN2MEN1 | |
| SCHEMBL29891629 | 0.77 | PDE4A (0.51) | ALDH1A1KMT2APKMSMN1; SMN2MEN1 | |
| SCHEMBL13241879 | 0.77 | TP53 (0.55) | ALDH1A1KMT2AMEN1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582667-B1 | HETEROCYCLIC SUBSTITUTED METHOXYPHENYL DERIVATIVES WITH OXOGROUP, METHOD FOR PRODUCING SAME AND USE AS GPR40 RECEPTOR MODULATORS | SANOFI SA (FR) | 2014-03-19 | — | — | EP | disclosed |
| EP-2582667-B1 | HETEROCYCLIC SUBSTITUTED METHOXYPHENYL DERIVATIVES WITH OXOGROUP, METHOD FOR PRODUCING SAME AND USE AS GPR40 RECEPTOR MODULATORS | SANOFI SA (FR) | 2014-03-19 | — | — | EP | disclosed |
| US-8530413-B2 | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments | SANOFI (FR) | 2013-09-10 | — | — | US | disclosed |
| US-8530413-B2 | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments | SANOFI (FR) | 2013-09-10 | — | — | US | disclosed |
| US-8530413-B2 | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments | SANOFI (FR) | 2013-09-10 | — | — | US | disclosed |
| EP-2582667-A1 | HETEROCYCLIC SUBSTITUTED METHOXYPHENYL DERIVATIVES HAVING AN OXO GROUP, METHOD FOR PRODUCING SAME, AND USE THEREOF AS GPR40 RECEPTOR MODULATORS | SANOFI (FR) | 2013-04-24 | — | — | EP | disclosed |
| US-20120004165-A1 | HETEROCYCLICALLY SUBSTITUTED METHOXYPHENYL DERIVATIVES WITH AN OXO GROUP, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS | SANOFI (FR) | 2012-01-05 | — | — | US | disclosed |
| US-20120004165-A1 | HETEROCYCLICALLY SUBSTITUTED METHOXYPHENYL DERIVATIVES WITH AN OXO GROUP, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS | SANOFI (FR) | 2012-01-05 | — | — | US | disclosed |
| US-20120004165-A1 | HETEROCYCLICALLY SUBSTITUTED METHOXYPHENYL DERIVATIVES WITH AN OXO GROUP, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS | SANOFI (FR) | 2012-01-05 | — | — | US | disclosed |
| WO-2011161030-A1 | HETEROCYCLIC SUBSTITUTED METHOXYPHENYL DERIVATIVES HAVING AN OXO GROUP, METHOD FOR PRODUCING SAME, AND USE THEREOF AS GPR40 RECEPTOR MODULATORS | SANOFI (FR) | 2011-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004165-A1 | HETEROCYCLICALLY SUBSTITUTED METHOXYPHENYL DERIVATIVES WITH AN OXO GROUP, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS | CYP4B1, CYP4F3, CYP11B1 | ALDH1A1 1410/4885KMT2A 4179/4885PKM 517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.