Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ANPEP | P15144 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247762 | 0.88 | ALDH1A1 (0.46) | KMT2AMEN1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL7836213 | 0.84 | TP53 (0.46) | KMT2AMEN1PKMALDH1A1TP53 | |
| SCHEMBL7825844 | 0.82 | PARK7 (0.47) | KMT2AMEN1MAPTLMNAANPEP | |
| SCHEMBL7836004 | 0.82 | LMNA (0.46) | KMT2AMEN1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL5007556 | 0.82 | HSPA9 (0.39) | KMT2AMEN1TP53MAPTLMNA | |
| SCHEMBL30642207 | 0.81 | ANPEP (0.49) | KMT2AMEN1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL26640052 | 0.81 | ANPEP (0.49) | KMT2AMEN1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL26756233 | 0.81 | CUL4A (0.55) | KMT2AMEN1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL7833333 | 0.80 | TDP1 (0.46) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL7832671 | 0.79 | MEN1 (0.44) | KMT2AMEN1PKMTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780388-B1 | 5HT1Dalpha and 5HT2A ligands | LILLY CO ELI (GB) | 2001-08-16 | — | — | EP | disclosed |
| US-6166040-A | Indole compounds | ELI LILLY AND COMPANY LIMITED (GB) | 2000-12-26 | — | — | US | disclosed |
| EP-0963983-A1 | Indol-2-ones as serotonin modulators | ELI LILLY AND COMPANY LIMITED (GB) | 1999-12-15 | — | — | EP | disclosed |
| US-5773448-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1998-06-30 | — | — | US | disclosed |
| CN-1157822-A | Pharmaceutical compounds | LILLY INDUSTRIES LTD (GB) | 1997-08-27 | — | — | CN | disclosed |
| EP-0780388-A1 | 5HT1Dalpha and 5HT2A ligands | LILLY INDUSTRIES LIMITED (GB) | 1997-06-25 | — | — | EP | disclosed |