Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.77 |
| ▸ | HTT | P42858 | 5/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.77 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.77 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.77 |
| ▸ | MITF | O75030 | 3/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 9/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MGAM | O43451 | 2/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SI | P14410 | 2/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31172052 | 0.87 | ALDH1A1 (1.00) | MAPTALDH1A1HTTSMN1; SMN2S1PR4 | |
| SCHEMBL31172053 | 0.82 | ALDH1A1 (0.80) | MAPTALDH1A1HTTSMN1; SMN2S1PR4 | |
| SCHEMBL29451310 | 0.82 | ALDH1A1 (0.53) | MAPTALDH1A1HTTSMN1; SMN2S1PR4 | |
| SCHEMBL24779603 | 0.81 | MAPT (0.69) | MAPTALDH1A1HTTSMN1; SMN2S1PR4 | |
| SCHEMBL24780884 | 0.77 | MAPT (0.63) | MAPTALDH1A1HTTSMN1; SMN2S1PR4 | |
| SCHEMBL24780120 | 0.76 | ALDH1A1 (0.74) | MAPTALDH1A1HTTSMN1; SMN2S1PR4 | |
| SCHEMBL30158331 | 0.76 | ALDH1A1 (0.70) | MAPTALDH1A1HTTSMN1; SMN2S1PR4 | |
| SCHEMBL29451328 | 0.75 | MEN1 (0.51) | MAPTALDH1A1HTTSMN1; SMN2S1PR4 | |
| SCHEMBL27514400 | 0.75 | MAPT (0.55) | MAPTALDH1A1HTTSMN1; SMN2S1PR4 | |
| SCHEMBL31172061 | 0.75 | ALDH1A1 (0.70) | MAPTALDH1A1HTTSMN1; SMN2S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022258992-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | UNIVERSITETET I OSLO (NO) | 2022-12-15 | — | — | WO | disclosed |