Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.70 |
| ▸ | HTT | P42858 | 13/20 | 0.70 |
| ▸ | MITF | O75030 | 8/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.70 |
| ▸ | MAPT | P10636 | 7/20 | 0.70 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.70 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 9/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 10/20 | 0.65 |
| ▸ | LMNA | P02545 | 8/20 | 0.65 |
| ▸ | NPC1 | O15118 | 8/20 | 0.54 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31172053 | 0.85 | ALDH1A1 (0.80) | ALDH1A1HTTMITFSMN1; SMN2MAPT | |
| SCHEMBL30158470 | 0.85 | ALDH1A1 (0.70) | ALDH1A1HTTMITFSMN1; SMN2MAPT | |
| SCHEMBL31172052 | 0.82 | ALDH1A1 (1.00) | ALDH1A1HTTMITFSMN1; SMN2MAPT | |
| SCHEMBL31172061 | 0.81 | ALDH1A1 (0.70) | ALDH1A1HTTMITFSMN1; SMN2MAPT | |
| SCHEMBL24780120 | 0.80 | ALDH1A1 (0.74) | ALDH1A1HTTMITFSMN1; SMN2MAPT | |
| SCHEMBL2894717 | 0.78 | ALDH1A1 (0.72) | ALDH1A1HTTMITFSMN1; SMN2MAPT | |
| SCHEMBL24780121 | 0.77 | ALDH1A1 (0.74) | ALDH1A1HTTMITFSMN1; SMN2MAPT | |
| SCHEMBL24779795 | 0.76 | MAPT (0.77) | ALDH1A1HTTMITFSMN1; SMN2MAPT | |
| SCHEMBL31172062 | 0.75 | ALDH1A1 (0.71) | ALDH1A1HTTMITFSMN1; SMN2MAPT | |
| SCHEMBL2888078 | 0.74 | HTT (0.69) | ALDH1A1HTTMITFSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4351518-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | Universitetet I Oslo (NO) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022258992-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | UNIVERSITETET I OSLO (NO) | 2022-12-15 | — | — | WO | disclosed |