Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24783527 | 0.77 | MAPT (0.33) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23788031 | 0.75 | HPGD (0.38) | MAPTKDM4EALDH1A1HPGDAPP | |
| SCHEMBL24783702 | 0.73 | MAPT (0.34) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24697490 | 0.70 | HPGD (0.36) | MAPTKDM4EALDH1A1HPGDAPP | |
| SCHEMBL24042269 | 0.69 | MAPT (0.57) | MAPTALDH1A1POLBHPGDRECQL | |
| SCHEMBL23615915 | 0.69 | APP (0.42) | MAPTKDM4EALDH1A1POLBHPGD | |
| SCHEMBL28385314 | 0.68 | MAPT (0.38) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21369288 | 0.66 | KIF11 (0.52) | — | |
| SCHEMBL23033391 | 0.66 | APP (0.49) | MAPTKDM4EALDH1A1POLBAPP | |
| SCHEMBL19674183 | 0.66 | BRD4 (0.34) | MAPTKDM4EALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4104861-A1 | THERAPEUTIC AGENT FOR TAUOPATHIES | Sumitomo Pharma Co., Ltd. (JP) | 2022-12-21 | — | — | EP | disclosed |