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Tobramycin

Tobramycin

SCHEMBL2478754

CCCCCCCCCCCCCCCCCC(=O)O.NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsU

The experimentally established mechanism targets of Tobramycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 2/20 0.73
▸ HPSE Q9Y251 1/20 0.73
▸ CYP3A4 P08684 1/20 0.73
▸ GAA P10253 1/20 0.70
▸ GJB2 P29033 6/20 0.63
▸ GJA1 P17302 1/20 0.58
▸ MEN1 O00255 1/20 0.58
▸ CYP2C9 P11712 1/20 0.58
▸ TSHR P16473 1/20 0.58
▸ KMT2A Q03164 1/20 0.58
▸ ALDH1A1 P00352 1/20 0.58
▸ KDM4E B2RXH2 1/20 0.57
▸ MAPT P10636 1/20 0.56
▸ LMNA P02545 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tobramycin SCHEMBL316999 1.00 ALOX15 (0.73) ALOX15HPSECYP3A4GAAGJB2
Tobramycin SCHEMBL2526940 1.00 ALOX15 (0.73) ALOX15HPSECYP3A4GAAGJB2
Tobramycin SCHEMBL4934969 1.00 ALOX15 (0.73) ALOX15HPSECYP3A4GAAGJB2
Tobramycin SCHEMBL1177718 1.00 ALOX15 (0.73) ALOX15HPSECYP3A4GAAGJB2
Tobramycin SCHEMBL317114 1.00 ALOX15 (0.73) ALOX15HPSECYP3A4GAAGJB2
Tobramycin SCHEMBL22722916 0.91 ALOX15 (0.71) ALOX15HPSECYP3A4GAAGJB2
Tobramycin SCHEMBL1178021 0.88 ALOX15 (0.87) ALOX15HPSECYP3A4GAAGJB2
Tobramycin SCHEMBL6439170 0.87 GAA (0.78) ALOX15HPSECYP3A4GAAGJB2
Tobramycin SCHEMBL17496961 0.87 ALOX15 (0.89) ALOX15HPSECYP3A4GAAGJB2
Tobramycin SCHEMBL3658310 0.86 ALOX15 (1.00) ALOX15HPSECYP3A4GAAGJB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1820496-B1 Method of manufacturing a medical device for implantation HERAEUS KULZER GMBH (DE) 2011-10-12 — — EP claimed
US-7858109-B2 Implant material HERAEUS KULZER GMBH (DE) 2010-12-28 — — US claimed
US-20070190109-A1 IMPLANT MATERIAL HERAEUS KULZER GMBH (DE) 2007-08-16 — — US claimed
CN-104338177-B Biological absorbable composite containing magnesium and magnesium alloy and the implant being made from it 贺利氏医疗有限公司 2017-09-01 — — CN disclosed
US-9700657-B2 Bio-absorbable composite materials containing magnesium and magnesium alloys as well as implants made of said composites HERAEUS MEDICAL GMBH (DE) 2017-07-11 — — US disclosed
CN-104338177-A BIO-ABSORBABLE COMPOSITE MATERIALS CONTAINING MAGNESIUM AND MAGNESIUM ALLOYS AS WELL AS IMPLANTS MADE OF SAID COMPOSITES HERAEUS MEDICAL GMBH 2015-02-11 — — CN disclosed
US-20150032201-A1 BIO-ABSORBABLE COMPOSITE MATERIALS CONTAINING MAGNESIUM AND MAGNESIUM ALLOYS AS WELL AS IMPLANTS MADE OF SAID COMPOSITES MEDIZINISCHE UNIVERSITÄT GRAZ (AT) 2015-01-29 — — US disclosed
US-7858109-B2 Implant material HERAEUS KULZER GMBH (DE) 2010-12-28 — — US disclosed
US-7858109-B2 Implant material HERAEUS KULZER GMBH (DE) 2010-12-28 — — US disclosed
CN-101023926-A Implant material HERAEUS KULZER GMBH (DE) 2007-08-29 — — CN disclosed
US-20070190109-A1 IMPLANT MATERIAL HERAEUS KULZER GMBH (DE) 2007-08-16 — — US disclosed
US-20070190109-A1 IMPLANT MATERIAL HERAEUS KULZER GMBH (DE) 2007-08-16 — — US disclosed