Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsU
The experimentally established mechanism targets of Tobramycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.72 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GJB2 | P29033 | 6/20 | 0.57 |
| ▸ | GJA1 | P17302 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tobramycin SCHEMBL4936988 | 0.90 | GAA (0.75) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL8573253 | 0.88 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL9712239 | 0.88 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL2837 | 0.88 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL2637031 | 0.88 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL1561126 | 0.88 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL2478754 | 0.87 | ALOX15 (0.73) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL4934969 | 0.87 | ALOX15 (0.73) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL316999 | 0.87 | ALOX15 (0.73) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL317114 | 0.87 | ALOX15 (0.73) | GAAALOX15HPSECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1398046-B1 | Antibioticum-/Antibiotica-polymer composite | HERAEUS KULZER GMBH (DE) | 2005-07-27 | — | — | EP | claimed |
| US-20040137065-A1 | Antibiotic polymer combination/antibiotics polymer combination | HERAEUS KULZER GMBH & CO. KG (DE) | 2004-07-15 | — | — | US | claimed |
| US-20040137065-A1 | Antibiotic polymer combination/antibiotics polymer combination | HERAEUS KULZER GMBH & CO. KG (DE) | 2004-07-15 | — | — | US | disclosed |