Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR39 | O43194 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 13/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.46 |
| ▸ | CDK9 | P50750 | 4/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30083382 | 0.89 | GPR39 (0.48) | GPR39CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL24791491 | 0.88 | GPR39 (0.44) | GPR39CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL30083417 | 0.87 | GPR39 (0.45) | GPR39CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL24791494 | 0.87 | GPR39 (0.43) | GPR39CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL30083612 | 0.87 | GPR39 (0.45) | GPR39CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL24791444 | 0.86 | CDK2 (0.49) | GPR39CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL30083466 | 0.86 | CDK2 (0.49) | GPR39CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL24792406 | 0.86 | CDK2 (0.48) | GPR39CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL24791650 | 0.85 | GSK3B (0.56) | GPR39CDK2CCNA2CCNT1CDK9 | |
| SCHEMBL24791639 | 0.85 | CDK2 (0.44) | GPR39CDK2CCNA2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |