Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | GPR39 | O43194 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 5/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 5/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24791444 | 1.00 | CDK2 (0.49) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL24791650 | 0.92 | GSK3B (0.56) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL24792972 | 0.91 | CDK7 (0.46) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL24791488 | 0.87 | GPR39 (0.43) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL24791659 | 0.87 | CDK2 (0.45) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL24791684 | 0.87 | CDK2 (0.45) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL24791683 | 0.87 | CDK2 (0.45) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL24792971 | 0.87 | CDK2 (0.47) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL24792977 | 0.87 | GPR39 (0.42) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL24792999 | 0.86 | GPR39 (0.48) | CDK2CHEK1CCNA2CCNA1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940427-A | Substituted pyrazolo [1,5-a ] pyrimidine-7-amine compounds as CDK inhibitors and therapeutic uses thereof | 卡里克治疗有限公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-4355426-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |