Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30467955 | 0.95 | LMNA (0.45) | P2RX4LMNACA2CA12CA1 | |
| SCHEMBL1700083 | 0.95 | LMNA (0.45) | P2RX4LMNACA2CA12CA1 | |
| SCHEMBL1700104 | 0.95 | LMNA (0.45) | P2RX4LMNACA2CA12CA1 | |
| SCHEMBL1699894 | 0.95 | LMNA (0.45) | P2RX4LMNACA2CA12CA1 | |
| SCHEMBL25306920 | 0.79 | LMNA (0.44) | LMNACA2CA12CA1CA9 | |
| SCHEMBL1957627 | 0.79 | P2RX4 (0.53) | P2RX4LMNACA2CA12CA1 | |
| SCHEMBL1700347 | 0.78 | HTR2A (0.46) | LMNACA2CA12CA1CA9 | |
| SCHEMBL1700056 | 0.77 | LMNA (0.51) | P2RX4LMNACA2CA12CA1 | |
| SCHEMBL28570751 | 0.77 | LMNA (0.42) | LMNACA2CA12CA1CA9 | |
| SCHEMBL1700726 | 0.75 | HRH3 (0.46) | LMNAMAPTBCL2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376480-A2 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | Abbott Laboratories (US) | 2011-10-19 | — | — | EP | disclosed |