Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 12/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | TACR2 | P21452 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2477257 | 0.94 | TACR3 (0.54) | TACR3DRD2DRD4 | |
| SCHEMBL2480227 | 0.93 | OPRM1 (0.45) | TACR3DRD2DRD4TACR2TACR1 | |
| SCHEMBL2480300 | 0.91 | TACR3 (0.46) | TACR3DRD2DRD4TACR2TACR1 | |
| SCHEMBL2478604 | 0.90 | TACR3 (0.52) | TACR3TACR2TACR1 | |
| SCHEMBL2474067 | 0.89 | TACR3 (0.51) | TACR3 | |
| SCHEMBL2476664 | 0.89 | TACR3 (0.58) | TACR3PKMHTTSMN1; SMN2 | |
| SCHEMBL2479924 | 0.88 | TACR3 (0.55) | TACR3DRD2DRD4TACR2TACR1 | |
| SCHEMBL2477434 | 0.88 | TACR3 (0.59) | TACR3TACR2TACR1 | |
| SCHEMBL2480905 | 0.87 | TACR3 (0.51) | TACR3 | |
| SCHEMBL2477433 | 0.85 | TACR3 (0.53) | TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656349-B1 | CYCLOPROPYL DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2011-10-12 | — | — | EP | claimed |