Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | TACR3 | P29371 | 11/20 | 0.44 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480905 | 0.93 | TACR3 (0.51) | TACR3 | |
| SCHEMBL2479990 | 0.93 | TACR3 (0.46) | TACR3TACR2TACR1DRD2DRD4 | |
| SCHEMBL2474067 | 0.92 | TACR3 (0.51) | TACR3 | |
| SCHEMBL2478604 | 0.89 | TACR3 (0.52) | TACR3TACR2TACR1 | |
| SCHEMBL2477331 | 0.88 | TACR3 (0.58) | OPRM1TACR3TACR2TACR1DRD2 | |
| SCHEMBL2477257 | 0.88 | TACR3 (0.54) | TACR3DRD2DRD4 | |
| SCHEMBL2480243 | 0.86 | TACR3 (0.56) | TACR3TACR2TACR1 | |
| SCHEMBL2477433 | 0.85 | TACR3 (0.53) | TACR3 | |
| SCHEMBL2480300 | 0.85 | TACR3 (0.46) | TACR3TACR2TACR1DRD2DRD4 | |
| SCHEMBL2477328 | 0.82 | TACR3 (0.53) | TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656349-B1 | CYCLOPROPYL DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2011-10-12 | — | — | EP | claimed |