Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24800992 | 0.75 | APP (0.43) | TERTAPPPSMB5NPC1RAB9A | |
| SCHEMBL18227093 | 0.75 | TERT (0.49) | TERTAPPPSMB5NPC1RAB9A | |
| SCHEMBL16739391 | 0.75 | TERT (0.49) | TERTAPPPSMB5NPC1RAB9A | |
| SCHEMBL18227070 | 0.75 | TERT (0.49) | TERTAPPPSMB5NPC1RAB9A | |
| SCHEMBL24800997 | 0.74 | CDK5 (0.43) | TERTAPPNPC1RAB9ACCNT1 | |
| SCHEMBL31089909 | 0.74 | CDK5 (0.43) | TERTAPPNPC1RAB9ACCNT1 | |
| SCHEMBL18227073 | 0.71 | TERT (0.47) | TERTAPPPSMB5NPC1RAB9A | |
| SCHEMBL18227144 | 0.69 | TERT (0.49) | TERTAPPPSMB5NPC1RAB9A | |
| SCHEMBL22969407 | 0.69 | GRK2 (0.40) | MAOBMAOAGRK2MEN1KMT2A | |
| SCHEMBL29495787 | 0.69 | GRK2 (0.40) | MAOBMAOAGRK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271676-A1 | INDOLE-SUBSTITUTED QUINOLINES AND THEIR COMBINATION WITH PLK1 INHIBITORS FOR THE TREATMENT OF CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2022-12-29 | — | — | WO | disclosed |