Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | C1S | P09871 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24800989 | 0.76 | APP (0.57) | APPTERTRAB9ANPC1GAA | |
| SCHEMBL24800994 | 0.75 | TERT (0.43) | APPTERTRAB9ANPC1PSMB5 | |
| SCHEMBL16739391 | 0.75 | TERT (0.49) | APPTERTRAB9ANPC1ATM | |
| SCHEMBL18227093 | 0.75 | TERT (0.49) | APPTERTRAB9ANPC1ATM | |
| SCHEMBL18227070 | 0.75 | TERT (0.49) | APPTERTRAB9ANPC1ATM | |
| SCHEMBL24800997 | 0.74 | CDK5 (0.43) | APPTERTRAB9ANPC1MAPT | |
| SCHEMBL31089909 | 0.74 | CDK5 (0.43) | APPTERTRAB9ANPC1MAPT | |
| SCHEMBL24800990 | 0.74 | SREBF2 (0.44) | APPTERTRAB9ANPC1MAPT | |
| SCHEMBL18227073 | 0.71 | TERT (0.47) | APPTERTRAB9ANPC1PSMB5 | |
| SCHEMBL11559475 | 0.70 | ERN1 (0.46) | RAB9ANPC1GAAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271676-A1 | INDOLE-SUBSTITUTED QUINOLINES AND THEIR COMBINATION WITH PLK1 INHIBITORS FOR THE TREATMENT OF CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2022-12-29 | — | — | WO | disclosed |