SCHEMBL2480145

SCHEMBL2480145

CCCCC(C)CC.COc1cccc2onc(C(N)=O)c12

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 2/20 0.37
TSHR P16473 1/20 0.36
KCNA5 P22460 2/20 0.35
EDNRA P25101 1/20 0.34
IKBKB O14920 1/20 0.34
PPARA Q07869 2/20 0.33
DHFR P00374 1/20 0.33
EGFR P00533 1/20 0.33
NQO1 P15559 1/20 0.33
PPARG P37231 1/20 0.33
HTR4 Q13639 1/20 0.33
CTDSP1 Q9GZU7 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
APLNR P35414 1/20 0.33
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
ALOX15 P16050 1/20 0.32
RAB9A P51151 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2467786 0.87 HIF1A (0.40) HIF1ATSHRKCNA5EDNRAIKBKB
SCHEMBL2480146 0.83 DHFR (0.40) TSHRKCNA5DHFREGFRHTR4
SCHEMBL2439957 0.72 TSHR (0.51) HIF1ATSHRKCNA5ALDH1A1MEN1
SCHEMBL30422301 0.72 KCNA5 (0.44) HIF1ATSHRKCNA5KMT2AKIT
SCHEMBL21232730 0.72 HIF1A (0.49) HIF1AKCNA5EDNRANQO1ALDH1A1
SCHEMBL2438936 0.72 ALDH1A1 (0.40) HIF1ATSHRALDH1A1LMNAKMT2A
SCHEMBL2467788 0.69 KCNA5 (0.41) KCNA5DHFREGFRNQO1HTR4
SCHEMBL2310118 0.69 IKBKE (0.43) HIF1ATSHRNPC1HPGDRAB9A
SCHEMBL2439113 0.68 TSHR (0.48) HIF1ATSHRKCNA5ALDH1A1HPGD
SCHEMBL2440327 0.68 KCNA5 (0.48) HIF1AKCNA5ALDH1A1HPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893589-B1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS GRUENENTHAL GMBH (DE) 2011-09-14 EP claimed