Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24233561 | 0.84 | MEN1 (0.43) | HPGDKCNH2MEN1KMT2ANPC1 | |
| SCHEMBL21835399 | 0.83 | PRKAB2 (0.40) | KCNH2MEN1KMT2AL3MBTL1PARP1 | |
| SCHEMBL454756 | 0.83 | PRKAB2 (0.40) | KCNH2MEN1KMT2AL3MBTL1PARP1 | |
| SCHEMBL23323171 | 0.81 | CREBBP (0.51) | CREBBPMEN1KMT2ABRD4PARP1 | |
| Oxalic Acid SCHEMBL28871384 | 0.75 | HCAR2 (0.40) | KCNH2MEN1KMT2APARP1 | |
| Oxalic Acid SCHEMBL28871386 | 0.75 | HCAR2 (0.40) | KCNH2MEN1KMT2APARP1 | |
| SCHEMBL21494179 | 0.74 | HTR2A (0.41) | KCNH2MEN1KMT2ACCNT1CDK9 | |
| SCHEMBL21494180 | 0.74 | HTR2A (0.41) | KCNH2MEN1KMT2ACCNT1CDK9 | |
| SCHEMBL22097356 | 0.74 | MEN1 (0.44) | KCNH2MEN1KMT2AL3MBTL1CCNT1 | |
| SCHEMBL4102503 | 0.74 | MEN1 (0.44) | KCNH2MEN1KMT2AL3MBTL1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220409731-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220409731-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | ALK, BCR, FAP | CREBBP 1983/4885JAK2 2883/4885NTRK1 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.