Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.34 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28906820 | 0.86 | KDM4E (0.59) | KDM4ECFTRKMT2AALDH1A1MEN1 | |
| SCHEMBL12245665 | 0.84 | SMN1; SMN2 (0.45) | KDM4ESMN1; SMN2PTGS1ALDH1A1 | |
| SCHEMBL29945921 | 0.82 | KIF11 (0.38) | KDM4ECFTRKIF11KMT2APTGS1 | |
| SCHEMBL23301033 | 0.82 | CES2 (0.44) | KDM4ECFTRKIF11PTGS1ALDH1A1 | |
| SCHEMBL29656849 | 0.82 | CES2 (0.44) | KDM4ECFTRKIF11PTGS1ALDH1A1 | |
| SCHEMBL23526580 | 0.82 | KIF11 (0.38) | KDM4ECFTRKIF11KMT2APTGS1 | |
| SCHEMBL24801801 | 0.81 | TMPRSS4 (0.39) | SMN1; SMN2HTTLMNAKIF11KMT2A | |
| SCHEMBL6119213 | 0.81 | CFTR (0.54) | KDM4ECFTRALDH1A1MAPT | |
| SCHEMBL5403595 | 0.81 | TMPRSS4 (0.40) | KDM4ECFTRSMN1; SMN2KIF11TMPRSS4 | |
| SCHEMBL18354453 | 0.80 | KIF11 (0.39) | SMN1; SMN2HTTLMNAKIF11KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271679-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-12-29 | — | — | WO | disclosed |