Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24801996 | 1.00 | MAPT (0.44) | MAPTGAASIGMAR1TMEM97ACHE | |
| SCHEMBL25590797 | 0.85 | SIGMAR1 (0.49) | MAPTSIGMAR1TMEM97 | |
| SCHEMBL15532630 | 0.83 | KDM4E (0.47) | LMNA | |
| SCHEMBL1508976 | 0.83 | MAPT (0.43) | MAPTSIGMAR1TMEM97ACHELMNA | |
| SCHEMBL1508882 | 0.83 | MAPT (0.43) | MAPTSIGMAR1TMEM97ACHELMNA | |
| SCHEMBL2486957 | 0.83 | MAPT (0.43) | MAPTSIGMAR1TMEM97ACHELMNA | |
| SCHEMBL4391046 | 0.76 | MAPT (0.47) | MAPTGAASIGMAR1TMEM97ACHE | |
| SCHEMBL21057421 | 0.73 | MAPT (0.45) | MAPTGAASIGMAR1TMEM97ACHE | |
| SCHEMBL6741206 | 0.72 | MAPT (0.68) | MAPTSIGMAR1ACHE | |
| SCHEMBL4048121 | 0.72 | MAPT (0.68) | MAPTSIGMAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359081-A1 | PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN | Novartis AG (CH) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022269508-A1 | PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN | NOVARTIS AG (CH) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022269508-A1 | PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN | NOVARTIS AG (CH) | 2022-12-29 | — | — | WO | disclosed |