Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.65 |
| ▸ | ACE | P12821 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | CTSS | P25774 | 3/20 | 0.54 |
| ▸ | CTSB | P07858 | 2/20 | 0.54 |
| ▸ | CTSK | P43235 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MDM4 | O15151 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080212 | 0.98 | KLK5 (0.67) | KLK5ACEATMCTSSCTSB | |
| SCHEMBL28582380 | 0.92 | KLK5 (0.59) | KLK5ACEATMCTSSCTSB | |
| SCHEMBL23332639 | 0.92 | KLK5 (0.59) | KLK5ACEATMCTSSCTSB | |
| SCHEMBL30872660 | 0.91 | MAPT (0.54) | KLK5ACECTSSCTSBCTSK | |
| SCHEMBL11524728 | 0.91 | MAPT (0.54) | KLK5ACECTSSCTSBCTSK | |
| SCHEMBL11862942 | 0.91 | ACE (0.66) | KLK5ACEATMCTSSCTSB | |
| SCHEMBL18495333 | 0.91 | ACE (0.66) | KLK5ACEATMCTSSCTSB | |
| SCHEMBL29275120 | 0.90 | MDM4 (0.55) | KLK5CTSSCTSKALDH1A1KMT2A | |
| SCHEMBL19557762 | 0.89 | ACE (0.56) | KLK5ACEATMCTSSCTSB | |
| SCHEMBL2482019 | 0.89 | REN (0.60) | KLK5CTSSCTSBCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9024093-B2 | Fluorination of organic compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-05-05 | — | — | US | disclosed |
| US-9024093-B2 | Fluorination of organic compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-05-05 | — | — | US | disclosed |
| US-20110312903-A1 | FLUORINATION OF ORGANIC COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2011-12-22 | — | — | US | disclosed |
| US-20110312903-A1 | FLUORINATION OF ORGANIC COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2011-12-22 | — | — | US | disclosed |
| EP-2376408-A2 | FLUORINATION OF ORGANIC COMPOUNDS | President and Fellows of Harvard College (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010059943-A2 | FLUORINATION OF ORGANIC COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059943-A2 | FLUORINATION OF ORGANIC COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312903-A1 | FLUORINATION OF ORGANIC COMPOUNDS | SLCO1B3, SLCO2B1, FLI1 | KLK5 3379/4885ACE 3215/4885ATM 3496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.