Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.80 |
| ▸ | NQO2 | P16083 | 1/20 | 0.80 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480684 | 0.91 | MET (0.82) | METNQO2 | |
| SCHEMBL1296715 | 0.90 | MET (0.76) | METNQO2CHRM4 | |
| SCHEMBL29223103 | 0.90 | MET (0.80) | METNQO2CHRM4 | |
| SCHEMBL31690377 | 0.90 | MET (0.80) | METNQO2CHRM4 | |
| Tepotinib SCHEMBL1296895 | 0.89 | MET (1.00) | METNQO2 | |
| Tepotinib SCHEMBL29379106 | 0.89 | MET (1.00) | METNQO2 | |
| SCHEMBL31690421 | 0.88 | MET (0.80) | METNQO2 | |
| SCHEMBL30905887 | 0.88 | MET (0.80) | METNQO2CHRM4 | |
| Tepotinib SCHEMBL1295616 | 0.88 | MET (0.98) | METNQO2 | |
| Tepotinib SCHEMBL29550043 | 0.88 | MET (0.98) | METNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117794541-A | Compounds for the treatment of glioblastoma | 默克专利股份公司 | 2024-03-29 | — | — | CN | disclosed |
| EP-2373640-A1 | NOVEL POLYMORPHIC FORMS OF 3-(1-{3-[5-(1-METHYL-PIPERIDIN-4YLMETHOXY)-PYRIMIDIN-2-YL]-BENZYL}-6-OXO-1,6-DIHYDRO-PYRIDAZIN-3-YL)-BENZONITRILE HYDROCHLORIDE SALT AND PROCESSES OF MANUFACTURING THEREOF | Merck Patent GmbH (DE) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010078897-A1 | NOVEL POLYMORPHIC FORMS OF 3-(1-{3-[5-(1-METHYL-PIPERIDIN-4YLMETHOXY)-PYRIMIDIN-2-YL]-BENZYL}-6-OXO-1,6-DIHYDRO-PYRIDAZIN-3-YL)-BENZONITRILE HYDROCHLORIDE SALT AND PROCESSES OF MANUFACTURING THEREOF | MERCK PATENT GMBH (DE) | 2010-07-15 | — | — | WO | disclosed |