Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CEL | P19835 | 1/20 | 0.42 |
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318801 | 0.83 | CDK2 (0.43) | CDK2 | |
| SCHEMBL4716903 | 0.79 | FEN1 (0.36) | PNPFEN1CDK2HRH4HTR3A | |
| SCHEMBL1775677 | 0.74 | — | — | |
| SCHEMBL27508151 | 0.72 | HRH4 (0.42) | PNPFEN1CDK2HRH4HTR3A | |
| SCHEMBL2480765 | 0.71 | ADORA2A (0.41) | MEN1KMT2A | |
| SCHEMBL25147465 | 0.71 | DHFR (0.49) | — | |
| SCHEMBL1091252 | 0.70 | HRH3 (0.42) | FEN1CDK2HRH4ALOX5APMEN1 | |
| SCHEMBL2480391 | 0.70 | PNP (0.56) | CELPNPFEN1HRH4HTR3A | |
| SCHEMBL14291679 | 0.70 | DHFR (0.37) | — | |
| SCHEMBL2634024 | 0.68 | DHFR (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114408-B1 | SUBSTITUTED AMINOPYRIMIDINES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-12 | — | — | EP | disclosed |
| EP-2114408-B1 | SUBSTITUTED AMINOPYRIMIDINES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-12 | — | — | EP | disclosed |
| US-20100113492-A1 | Substituted Aminopyrimidines as Cholecystokinin-1 Receptor Modulators | MERCK & CO., INC. (US) | 2010-05-06 | — | — | US | disclosed |
| US-20100113492-A1 | Substituted Aminopyrimidines as Cholecystokinin-1 Receptor Modulators | MERCK & CO., INC. (US) | 2010-05-06 | — | — | US | disclosed |
| US-20100113492-A1 | Substituted Aminopyrimidines as Cholecystokinin-1 Receptor Modulators | MERCK & CO., INC. (US) | 2010-05-06 | — | — | US | disclosed |
| WO-2008091631-A1 | SUBSTITUTED AMINOPYRIMIDINES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113492-A1 | Substituted Aminopyrimidines as Cholecystokinin-1 Receptor Modulators | CCKAR, CCKBR, GLP1R | CEL 285/4885PNP 1105/4885FEN1 2971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.