Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2475976 | 0.84 | TACR3 (0.52) | HSD11B1MEN1KMT2ATACR3 | |
| SCHEMBL2476860 | 0.78 | TACR3 (0.57) | HSD11B1MEN1KMT2ATACR3ALDH1A1 | |
| SCHEMBL2481720 | 0.78 | TACR3 (0.57) | HSD11B1MEN1KMT2ATACR3ALDH1A1 | |
| SCHEMBL2474123 | 0.78 | TACR3 (0.53) | HSD11B1MEN1KMT2ATACR3 | |
| SCHEMBL2477738 | 0.77 | TACR3 (0.53) | HSD11B1TACR3 | |
| SCHEMBL2477328 | 0.76 | TACR3 (0.53) | HSD11B1MEN1KMT2ATACR3 | |
| SCHEMBL2476664 | 0.76 | TACR3 (0.58) | HSD11B1MEN1KMT2ATACR3ALDH1A1 | |
| SCHEMBL2477331 | 0.76 | TACR3 (0.58) | HSD11B1MEN1KMT2ATACR3ALDH1A1 | |
| SCHEMBL2480350 | 0.76 | TACR3 (0.67) | HSD11B1MEN1KMT2ATACR3 | |
| SCHEMBL2477401 | 0.76 | TACR3 (0.44) | HSD11B1MEN1KMT2ATACR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656349-B1 | CYCLOPROPYL DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2011-10-12 | — | — | EP | claimed |