⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6544503 | 0.66 | NEK2 (0.30) | — | |
| SCHEMBL14290351 | 0.60 | NEK2 (0.36) | — | |
| SCHEMBL7339315 | 0.60 | — | — | |
| SCHEMBL460791 | 0.55 | ITGB3 (0.30) | — | |
| SCHEMBL3313402 | 0.55 | — | — | |
| SCHEMBL13845917 | 0.54 | BACE1 (0.47) | — | |
| SCHEMBL3701448 | 0.53 | — | — | |
| SCHEMBL1032285 | 0.53 | TDO2 (0.40) | — | |
| SCHEMBL68772 | 0.53 | DDB1 (0.30) | — | |
| Water SCHEMBL10621554 | 0.52 | GAA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373169-A1 | IMIDAZOPYRAZINE SYK INHIBITORS | Gilead Connecticut, Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010068257-A1 | IMIDAZOPYRAZINE SYK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |