Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (R,R)-Tramadol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 0.82 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.82 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.82 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.82 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.82 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R,R)-Tramadol SCHEMBL2678195 | 0.92 | SLC6A2 (0.89) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL6543836 | 0.91 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL57495 | 0.91 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL7464 | 0.91 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL730723 | 0.91 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL12831358 | 0.91 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL11984200 | 0.91 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL1593740 | 0.91 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL5318670 | 0.91 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL3265792 | 0.91 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013150277-A1 | OPHTHALMIC THERAPY | SHARMA ANANT (GB) | 2013-10-10 | — | — | WO | claimed |
| US-8173164-B2 | Both active substances are contained in the same administration unit as two separately formulated subunits | GRUENENTHAL GMBH (DE) | 2012-05-08 | — | — | US | claimed |
| EP-2377514-A2 | Liquid parenteral formulation comprising a tramadol material and paracetamol | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. (GR) | 2011-10-19 | — | — | EP | claimed |
| EP-1183015-B1 | MULTILAYERED TABLET FOR ADMINISTRATION OF A FIXED COMBINATION OF TRAMADOL AND DICLOFENAC | GRUENENTHAL GMBH (DE) | 2004-10-20 | — | — | EP | claimed |
| US-20040115267-A1 | Oral administration forms for administering a fixed tramadol and diclofenac combination | GRUENENTHAL GMBH. | 2004-06-17 | — | — | US | claimed |
| EP-1185253-B1 | ORAL ADMINISTRATION FORM FOR ADMINISTERING A FIXED TRAMADOL AND DICLOFENAC COMBINATION | GRUENENTHAL GMBH (DE) | 2004-03-03 | — | — | EP | claimed |
| US-6558701-B2 | Multilayer tablet for administering a fixed combination of tramadol and diclofenac | GRUENENTHAL GMBH (DE) | 2003-05-06 | — | — | US | claimed |
| US-20020156133-A1 | Oral administration forms for administering a fixed tramadol and diclofenac combination | GRUENENTHAL GMBH (DE) | 2002-10-24 | — | — | US | claimed |
| US-20020132850-A1 | Multilayer tablet for administering a fixed combination of tramadol and diclofenac | GRUENENTHAL GMBH (DE) | 2002-09-19 | — | — | US | claimed |
| US-8173164-B2 | Both active substances are contained in the same administration unit as two separately formulated subunits | GRUENENTHAL GMBH (DE) | 2012-05-08 | — | — | US | disclosed |
| EP-2377514-A2 | Liquid parenteral formulation comprising a tramadol material and paracetamol | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. (GR) | 2011-10-19 | — | — | EP | disclosed |
| US-20040115267-A1 | Oral administration forms for administering a fixed tramadol and diclofenac combination | GRUENENTHAL GMBH. | 2004-06-17 | — | — | US | disclosed |
| US-6558701-B2 | Multilayer tablet for administering a fixed combination of tramadol and diclofenac | GRUENENTHAL GMBH (DE) | 2003-05-06 | — | — | US | disclosed |
| US-20020156133-A1 | Oral administration forms for administering a fixed tramadol and diclofenac combination | GRUENENTHAL GMBH (DE) | 2002-10-24 | — | — | US | disclosed |
| US-20020132850-A1 | Multilayer tablet for administering a fixed combination of tramadol and diclofenac | GRUENENTHAL GMBH (DE) | 2002-09-19 | — | — | US | disclosed |