Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (R,R)-Tramadol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 13/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 13/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 6/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 4/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R,R)-Tramadol SCHEMBL14579837 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL7464 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL12831358 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL6543836 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL3265792 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL5318670 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL11984200 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL730723 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL57495 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Tramadol SCHEMBL57496 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160039742-A1 | EXTRACTION OF TRAMADOL FROM NAUCLEA LATIFOLIA SMITH | UNIVERSITE JOSEPH FOURIER - GRENOBLE 1 (FR) | 2016-02-11 | — | — | US | claimed |
| US-12514833-B2 | Combination of ibuprofen and tramadol for relieving pain | FARMALÍDER, S.A. (ES) | 2026-01-06 | — | — | US | disclosed |
| EP-3996699-B1 | COMBINATION OF IBUPROFEN AND TRAMADOL FOR RELIEVING PAIN | FARMALIDER SA (ES) | 2023-06-28 | — | — | EP | disclosed |
| US-20220249414-A1 | COMBINATION OF IBUPROFEN AND TRAMADOL FOR RELIEVING PAIN | FARMALÍDER, S.A. (ES) | 2022-08-11 | — | — | US | disclosed |
| US-10781163-B2 | Process for preparation of O-Desmethyltramadol and salts thereof | R L FINECHEM PRIVATE LIMITED (IN) | 2020-09-22 | — | — | US | disclosed |
| US-20200231536-A1 | A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF | R L FINECHEM PRIVATE LIMITED (IN) | 2020-07-23 | — | — | US | disclosed |
| US-10292953-B2 | Pharmaceutical composition of ibuprofen and tramadol for ophthalmic use | FARMALIDER SA (ES) | 2019-05-21 | — | — | US | disclosed |
| WO-2019053494-A1 | A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF | R L FINE CHEM PRIVATE LIMITED (IN) | 2019-03-21 | — | — | WO | disclosed |
| EP-2474309-B1 | PHARMACEUTICAL COMPOSITION COMPRISING IBUPROFEN, TRAMADOL AND A BASIC AMINO ACID, PREPARATION METHOD THEREOF AND USE OF SAME | FARMALIDER SA (ES) | 2018-08-29 | — | — | EP | disclosed |
| EP-3348260-A1 | PHARMACEUTICAL TRAMADOL COMPOSITION FOR OPHTHALMIC USE | Farmalider, S.A. (ES) | 2018-07-18 | — | — | EP | disclosed |
| US-20030017117-A1 | Delivery of analgesics through an inhalation route | ALEXZA PHARMACEUTICALS, INC. | 2003-01-23 | — | — | US | disclosed |
| WO-2002094231-A1 | DELIVERY OF ANALGESICS THROUGH AN INHALATION ROUTE | ALEXZA MOLECULAR DELIVERY CORPORATION (US) | 2002-11-28 | — | — | WO | disclosed |
| US-6387956-B1 | ADMINISTERING TRAMADOL | UNIVERSITY OF CINCINNATI | 2002-05-14 | — | — | US | disclosed |
| US-6323368-B1 | RESOLVING RACEMIC TRAMADOL BY CLASSICAL SALT RESOLUTION USING A SUBSTANTIALLY SINGLE ENANTIOMER OF O,O-DI-P-TOLUOYLTARTARIC ACID AS A RESOLVING AGENT | DARWIN DISCOVERY, LTD. (GB) | 2001-11-27 | — | — | US | disclosed |
| EP-1135357-A1 | PROCESS FOR THE RESOLUTION OF TRAMADOL | Darwin Discovery Limited (GB) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000032554-A1 | PROCESS FOR THE RESOLUTION OF TRAMADOL | DARWIN DISCOVERY LIMITED (GB) | 2000-06-08 | — | — | WO | disclosed |
| WO-2000029022-A1 | COX-2 INHIBITORS IN COMBINATION WITH CENTRALLY ACTING ANALGESICS | ALGOS PHARMACEUTICAL CORPORATION (US) | 2000-05-25 | — | — | WO | disclosed |
| EP-0938305-A2 | METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST | Algos Pharmaceutical Corporation (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5919826-A | Method of alleviating pain | ALGOS PHARMACEUTICAL CORPORATION (US) | 1999-07-06 | — | — | US | disclosed |
| WO-1998017268-A2 | METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST | ALGOS PHARMACEUTICAL CORPORATION (US) | 1998-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200231536-A1 | A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF | CYP3A7, TET1, CYP3A4 | OPRM1 84/4885SLC6A2 109/4885SLC6A4 123/4885 |
| US-10781163-B2 | Process for preparation of O-Desmethyltramadol and salts thereof | TET1, TET2, TET3 | OPRM1 144/4885SLC6A2 151/4885SLC6A4 160/4885 |
| US-20160039742-A1 | EXTRACTION OF TRAMADOL FROM NAUCLEA LATIFOLIA SMITH | OPRK1, OPRD1, OPRM1 | OPRM1 3/4885SLC6A2 15/4885SLC6A4 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.