Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (R,R)-Tramadol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 13/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 13/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 6/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 4/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R,R)-Tramadol SCHEMBL11984200 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL57495 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL730723 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL6543836 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL7464 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Tramadol SCHEMBL57496 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL14579837 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL1593740 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL3265792 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL12831358 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1236758-C | Slow-releasing injection contg. hydrocastor oil/medicine (for treatment) solid dispersion microparticle | WANG YUWAN (CN) | 2006-01-18 | — | — | CN | claimed |
| CN-1461639-A | Slow-releasing injection contg. hydrocastor oil/medicine (for treatment) solid dispersion microparticle | WANG YUWAN (CN) | 2003-12-17 | — | — | CN | claimed |
| WO-2018148342-A1 | COMPRESSED OPEN FLOW ASSAY AND USE | ESSENLIX CORPORATION (US) | 2018-08-16 | — | — | WO | disclosed |
| EP-3137065-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | Pharnext (FR) | 2017-03-08 | — | — | EP | disclosed |
| CN-105814067-A | Prodrugs of pyridone amides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2016-07-27 | — | — | CN | disclosed |
| WO-2016040822-A1 | READY-TO-CONSTITUTE ANALYTICAL PLATFORMS FOR CHEMICAL ANALYSES AND QUANTIFICATION | PINPOINT TESTING, LLC (US) | 2016-03-17 | — | — | WO | disclosed |
| WO-2015165948-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2015-11-05 | — | — | WO | disclosed |
| CN-103443105-A | Chroman-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMA | 2013-12-11 | — | — | CN | disclosed |
| WO-2007078895-A2 | MODIFIED RELEASE FORMULATIONS OF TRAMADOL AND USES THEREOF | BIOVAIL LABORATORIES INTERNATIONAL S.R.L. (BB) | 2007-07-12 | — | — | WO | disclosed |
| CN-1960781-A | Therapeutic combination for treatment of alzheimers disease | WARNER LAMBERT CO (US) | 2007-05-09 | — | — | CN | disclosed |
| EP-1737539-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | Warner-Lambert Company LLC (US) | 2007-01-03 | — | — | EP | disclosed |
| US-7074430-B2 | Controlled release tramadol tramadol formulation | EURO-CELTIQUE S.A. (LU) | 2006-07-11 | — | — | US | disclosed |
| CN-1236758-C | Slow-releasing injection contg. hydrocastor oil/medicine (for treatment) solid dispersion microparticle | WANG YUWAN (CN) | 2006-01-18 | — | — | CN | disclosed |
| WO-2005099823-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | WARNER-LAMBERT COMPANY LLC (US) | 2005-10-27 | — | — | WO | disclosed |
| CN-1461639-A | Slow-releasing injection contg. hydrocastor oil/medicine (for treatment) solid dispersion microparticle | WANG YUWAN (CN) | 2003-12-17 | — | — | CN | disclosed |
| WO-2000040205-A2 | SUSTAINED RELEASE FORMULATION WITH REDUCED MOISTURE SENSITIVITY | COPLEY PHARMACEUTICAL INC. (US) | 2000-07-13 | — | — | WO | disclosed |