SCHEMBL2481314

Cc1cc2c(cc1C(F)(F)F)N(OC(=O)OC(C)(C)C)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 2)

	gene	UniProt	supporting neighbours	confidence
▸	CETP	P11597	10/20	0.39

▸	TACR1	P25103	10/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2494468	0.89	TACR1 (0.43)	CETPTACR1
SCHEMBL2494470	0.89	TACR1 (0.43)	CETPTACR1
SCHEMBL2481213	0.84	CETP (0.55)	CETP
SCHEMBL2478247	0.82	CETP (0.53)	CETP
SCHEMBL12200355	0.82	MEN1 (0.40)	CETPTACR1
SCHEMBL2479637	0.76	CETP (0.56)	CETP
SCHEMBL3537504	0.75	CETP (0.47)	CETPTACR1
SCHEMBL2127581	0.75	CETP (0.47)	CETPTACR1
SCHEMBL3535990	0.75	CETP (0.47)	CETPTACR1
SCHEMBL2476089	0.75	CETP (0.50)	CETPTACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1761522-B1	COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA	LILLY CO ELI (US)	2011-10-12	—	—	EP	claimed