Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24814978 | 0.86 | TNF (0.45) | ALDH1A1POLBL3MBTL1TNFKDM4E | |
| SCHEMBL24816171 | 0.86 | TNF (0.45) | ALDH1A1POLBL3MBTL1TNFKDM4E | |
| SCHEMBL30179171 | 0.85 | TNF (0.45) | ALDH1A1POLBL3MBTL1TNFKDM4E | |
| SCHEMBL28370724 | 0.85 | TNF (0.45) | ALDH1A1POLBL3MBTL1TNFKDM4E | |
| SCHEMBL20294609 | 0.85 | TNF (0.45) | ALDH1A1POLBL3MBTL1TNFKDM4E | |
| SCHEMBL29753352 | 0.84 | ALDH1A1 (0.39) | ALDH1A1POLBL3MBTL1TNFKDM4E | |
| SCHEMBL24814971 | 0.82 | ALDH1A1 (0.38) | ALDH1A1POLBL3MBTL1TNFKDM4E | |
| SCHEMBL29144184 | 0.80 | TNF (0.49) | ALDH1A1L3MBTL1TNFMAPK1LMNA | |
| SCHEMBL24813373 | 0.80 | TNF (0.49) | ALDH1A1L3MBTL1TNFMAPK1LMNA | |
| SCHEMBL30049141 | 0.80 | TNF (0.49) | ALDH1A1L3MBTL1TNFMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271557-A1 | PROCESSES FOR THE PREPARATION OF (S)-2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL) METHYL)BENZYL) AMINO)ISOINDOLINE-1,3-DIONE | CELGENE CORPORATION (US) | 2022-12-29 | — | — | WO | disclosed |