SCHEMBL24813897

SCHEMBL24813897

NC(=O)CCN1C(=O)Cc2ccccc2C1=O

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.62
ALDH1A1 P00352 4/20 0.62
GAA P10253 4/20 0.62
APAF1 O14727 3/20 0.62
MAPT P10636 2/20 0.62
HSD17B10 Q99714 2/20 0.62
CASP1 P29466 1/20 0.62
RAB9A P51151 1/20 0.62
BLM P54132 1/20 0.62
CASP7 P55210 1/20 0.62
MEN1 O00255 3/20 0.57
HPGD P15428 2/20 0.57
RNASEH1 O60930 1/20 0.53
ACHE P22303 1/20 0.49
CASP6 P55212 2/20 0.49
CASP3 P42574 1/20 0.49
SENP8 Q96LD8 1/20 0.49
SENP7 Q9BQF6 1/20 0.49
SENP6 Q9GZR1 1/20 0.49
TSHR P16473 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24811059 0.88 KMT2A (0.70) KMT2AALDH1A1GAAAPAF1MAPT
SCHEMBL31395586 0.88 KMT2A (0.70) KMT2AALDH1A1GAAAPAF1MAPT
SCHEMBL11645408 0.86 KMT2A (0.59) KMT2AALDH1A1GAAAPAF1MAPT
SCHEMBL11280189 0.83 KMT2A (0.68) KMT2AALDH1A1GAAAPAF1MAPT
SCHEMBL20124834 0.83 KMT2A (0.68) KMT2AALDH1A1GAAAPAF1MAPT
SCHEMBL29441539 0.82 ALDH1A1 (0.57) KMT2AALDH1A1GAAHSD17B10MEN1
SCHEMBL1477933 0.82 ALDH1A1 (0.57) KMT2AALDH1A1GAAHSD17B10MEN1
SCHEMBL11283988 0.80 KMT2A (0.64) KMT2AALDH1A1GAAAPAF1MAPT
SCHEMBL24811060 0.80 ALDH1A1 (0.53) KMT2AALDH1A1GAAAPAF1MAPT
SCHEMBL30102243 0.80 ALDH1A1 (0.53) KMT2AALDH1A1GAAAPAF1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022272133-A2 PROTEIN STABILIZING COMPOUNDS CONTAINING USP7 LIGANDS Stablix, Inc. (US) 2022-12-29 WO disclosed