Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | GRM8 | O00222 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | GRB2 | P62993 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.45 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16542431 | 0.94 | GRM8 (0.52) | HDAC1HDAC8GRM8GRM4GRB2 | |
| SCHEMBL25183013 | 0.94 | GRM8 (0.52) | HDAC1HDAC8GRM8GRM4GRB2 | |
| SCHEMBL21553586 | 0.88 | GRM8 (0.55) | HDAC1HDAC8GRM8GRM4GRB2 | |
| SCHEMBL22444936 | 0.88 | GRM8 (0.55) | HDAC1HDAC8GRM8GRM4GRB2 | |
| SCHEMBL10419950 | 0.83 | HDAC1 (0.53) | HDAC1HDAC8KIF11TAAR1 | |
| SCHEMBL27734494 | 0.82 | FDFT1 (0.50) | HDAC1HDAC8GRB2KIF11PTPN1 | |
| SCHEMBL27734496 | 0.82 | FDFT1 (0.50) | HDAC1HDAC8GRB2KIF11PTPN1 | |
| SCHEMBL23176817 | 0.81 | GRIK1 (0.64) | KIF11NOS1GRIK1POLBKMT2A | |
| SCHEMBL24816430 | 0.81 | GRIK1 (0.64) | KIF11NOS1GRIK1POLBKMT2A | |
| SCHEMBL17686507 | 0.81 | GRIK1 (0.64) | KIF11NOS1GRIK1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411362-A1 | DITERPENOID COMPOUNDS THAT ACT ON PROTEIN KINASE C (PKC) | K-GEN THERAPEUTICS, INC. | 2022-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411362-A1 | DITERPENOID COMPOUNDS THAT ACT ON PROTEIN KINASE C (PKC) | PRKCA, PRKCH, PRKCB | HDAC1 1272/4885HDAC8 507/4885GRM8 2441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.