Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | MERTK | Q12866 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2452081 | 0.90 | ROCK2 (0.38) | SYKEGFRTRPV1BRD4AURKA | |
| SCHEMBL2475554 | 0.90 | SYK (0.44) | ADORA3ADORA2AADORA1SYKEGFR | |
| SCHEMBL2446932 | 0.80 | SYK (0.46) | ADORA3SYKMERTKMEN1AURKA | |
| SCHEMBL2476632 | 0.79 | CYP3A4 (0.37) | SYK | |
| SCHEMBL2537540 | 0.76 | TRPV1 (0.46) | SYKTRPV1 | |
| SCHEMBL2485293 | 0.76 | HTR2C (0.37) | SYKTYRO3BRD4MERTK | |
| SCHEMBL2843371 | 0.76 | SYK (0.44) | ADORA3ADORA2AADORA1SYKMEN1 | |
| SCHEMBL2844684 | 0.75 | MAPT (0.46) | TRPV1JAK2JAK3 | |
| SCHEMBL2480773 | 0.75 | ADORA3 (0.44) | ADORA3ADORA2AADORA1SYKTRPV1 | |
| SCHEMBL8276435 | 0.74 | ROCK2 (0.41) | SYKTRPV1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |