SCHEMBL24818979

SCHEMBL24818979

Cn1cnnc1-c1cc(F)ccc1-c1cc(Cl)nc(-c2nc3cc(CN[C@@H]4CCC[C@@H]4O)cc(C(F)(F)F)c3[nH]2)c1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 1/20 0.34
▸ TRPV3 Q8NET8 2/20 0.31
▸ PDCD1 Q15116 1/20 0.31
▸ CD274 Q9NZQ7 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30152996 1.00 CBLB (0.34) CBLBTRPV3PDCD1CD274
SCHEMBL24821922 0.93 CBLB (0.41) CBLBTRPV3
SCHEMBL30152826 0.93 CBLB (0.41) CBLBTRPV3
SCHEMBL30152831 0.88 CBLB (0.34) CBLBTRPV3PDCD1CD274
SCHEMBL24818652 0.88 CBLB (0.34) CBLBTRPV3PDCD1CD274
SCHEMBL30152583 0.88 CBLB (0.34) CBLBTRPV3PDCD1CD274
SCHEMBL24818657 0.88 CBLB (0.34) CBLBTRPV3PDCD1CD274
SCHEMBL24820573 0.88 CBLB (0.34) CBLBTRPV3PDCD1CD274
SCHEMBL30152822 0.88 CBLB (0.34) CBLBTRPV3PDCD1CD274
SCHEMBL24819920 0.85 P2RX7 (0.31) CBLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed
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