Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | VSIR | Q9H7M9 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | CETP | P11597 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30153031 | 0.93 | VSIR (0.36) | HPGDNPC1RAB9AVSIRTP53 | |
| SCHEMBL24818959 | 0.93 | VSIR (0.36) | HPGDNPC1RAB9AVSIRTP53 | |
| SCHEMBL24820372 | 0.91 | VSIR (0.37) | HPGDNPC1RAB9AVSIRTP53 | |
| SCHEMBL24820719 | 0.91 | VSIR (0.37) | HPGDNPC1RAB9AVSIRLMNA | |
| SCHEMBL30152963 | 0.91 | VSIR (0.37) | HPGDNPC1RAB9AVSIRLMNA | |
| SCHEMBL30153035 | 0.91 | VSIR (0.37) | HPGDNPC1RAB9AVSIRTP53 | |
| SCHEMBL24820375 | 0.90 | VSIR (0.34) | HPGDVSIRLMNAGAA | |
| SCHEMBL24821892 | 0.90 | VSIR (0.34) | HPGDVSIRLMNAGAAMAOB | |
| SCHEMBL24818753 | 0.90 | VSIR (0.34) | HPGDVSIRCETPLMNAGAA | |
| SCHEMBL24820065 | 0.90 | VSIR (0.34) | HPGDVSIRLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |