SCHEMBL24819031

SCHEMBL24819031

Cn1cnnc1-c1cc(Cl)ccc1-c1ccnc(-c2nc3cc(C=O)cc(C(F)(F)F)c3o2)c1

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ KDM4C Q9H3R0 1/20 0.34
▸ EIF4EBP1 Q13541 1/20 0.31
▸ SCN9A Q15858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24820526 0.92 IDO1 (0.30) —
SCHEMBL30152647 0.92 IDO1 (0.30) —
SCHEMBL24819029 0.86 KDM4C (0.34) KDM4CEIF4EBP1
SCHEMBL24819026 0.85 KDM4C (0.37) KDM4CEIF4EBP1SCN9A
SCHEMBL30152601 0.80 CBLB (0.38) —
SCHEMBL24818958 0.80 CBLB (0.38) —
SCHEMBL24819028 0.80 CBLB (0.34) —
SCHEMBL24818753 0.79 VSIR (0.34) SCN9A
SCHEMBL24820501 0.79 CBLB (0.37) SCN9A
SCHEMBL30153254 0.79 CBLB (0.37) SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4359381-A1 CBL-B MODULATORS AND USES THEREOF Nimbus Clio, Inc. (US) 2024-05-01 — — EP disclosed
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed
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