SCHEMBL2481964

SCHEMBL2481964

CCCC(O)NC(=O)C(C)(C)N=NC(C)(C)C(=O)NC(O)CCC

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC7 Q8WUI4 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
HDAC9 Q9UKV0 1/20 0.32
HDAC5 Q9UQL6 1/20 0.32
CHRM1 P11229 1/20 0.31
AKR1A1 P14550 1/20 0.31
CHRM3 P20309 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
ADRA1A P35348 1/20 0.31
HRH1 P35367 1/20 0.31
DRD3 P35462 1/20 0.31
SLC6A3 Q01959 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC2 Q92769 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
CYP3A4 P08684 1/20 0.30
TSHR P16473 1/20 0.30
NFKB1 P19838 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28253440 0.76 EPHX1 (0.41) HDAC7HDAC8HDAC6HDAC9HDAC5
SCHEMBL1683540 0.73 POLB (0.31)
SCHEMBL15968053 0.70
SCHEMBL1025270 0.70 CA12 (0.32)
SCHEMBL1025269 0.70 CA12 (0.32)
SCHEMBL3130179 0.70
SCHEMBL7956652 0.70 SIGMAR1 (0.37) CYP3A4TSHR
SCHEMBL7956648 0.70 SIGMAR1 (0.37) CYP3A4TSHR
SCHEMBL851936 0.70
SCHEMBL6435427 0.69 RIPK1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9903021-B2 Method for using 3-coat-1-bake waterborne coating composition AXALTA COATINGS SYSTEMS IP CO., LLC (US) 2018-02-27 US disclosed
EP-2373750-B1 METHOD FOR USING 3-COAT-1-BAKE WATERBORNE COATING COMPOSITION COATINGS FOREIGN IP CO LLC (US) 2017-11-22 EP disclosed
US-20110256320-A1 METHOD FOR USING 3-COAT-1-BAKE WATERBORNE COATING COMPOSITION E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-10-20 US disclosed
EP-2373750-A2 METHOD FOR USING 3-COAT-1-BAKE WATERBORNE COATING COMPOSITION E. I. du Pont de Nemours and Company (US) 2011-10-12 EP disclosed
WO-2010078355-A2 METHOD FOR USING 3-COAT-1-BAKE WATERBORNE COATING COMPOSITION E.I. DU PONT DE NEMOURS AND COMPANY (US) 2010-07-08 WO disclosed
US-7718729-B2 Aqueous intermediate coating composition and method for forming multilayer coating film KANSAI PAINT CO., LTD. (JP) 2010-05-18 US disclosed
EP-1693429-B1 Aqueous intermediate coating composition and method for forming multilayer coating film KANSAI PAINT CO LTD (JP) 2007-12-12 EP disclosed
US-20060188656-A1 Aqueous intermediate coating composition and method for forming multilayer coating film KANSAI PAINT CO., LTD. (JP) 2006-08-24 US disclosed
EP-1693429-A1 Aqueous intermediate coating composition and method for forming multilayer coating film KANSAI PAINT CO., LTD. (JP) 2006-08-23 EP disclosed