Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | VSIR | Q9H7M9 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24818932 | 0.92 | KDM4E (0.40) | KCNH2CYP2D6GRIN2BVSIRALDH1A1 | |
| SCHEMBL30152743 | 0.92 | KCNH2 (0.39) | KCNH2CYP2D6GRIN2BVSIRALDH1A1 | |
| SCHEMBL24818733 | 0.92 | KCNH2 (0.39) | KCNH2CYP2D6GRIN2BVSIRALDH1A1 | |
| SCHEMBL24818734 | 0.92 | KCNH2 (0.39) | KCNH2CYP2D6GRIN2BVSIRALDH1A1 | |
| SCHEMBL24819863 | 0.91 | CD274 (0.39) | KCNH2VSIRPDCD1CD274 | |
| SCHEMBL30153084 | 0.91 | VSIR (0.40) | KCNH2CYP2D6GRIN2BVSIRPDCD1 | |
| SCHEMBL24820155 | 0.91 | VSIR (0.40) | KCNH2CYP2D6GRIN2BVSIRPDCD1 | |
| SCHEMBL24818964 | 0.90 | KCNH2 (0.36) | KCNH2CYP2D6GRIN2BVSIRPDCD1 | |
| SCHEMBL30153012 | 0.90 | KCNH2 (0.36) | KCNH2CYP2D6GRIN2BVSIRPDCD1 | |
| SCHEMBL24820273 | 0.89 | VSIR (0.40) | KCNH2CYP2D6GRIN2BVSIRPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |