Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | VSIR | Q9H7M9 | 5/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.32 |
| ▸ | HTR3A | P46098 | 2/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | CBLB | Q13191 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24818964 | 1.00 | KCNH2 (0.36) | KCNH2VSIRPDCD1CD274HTR3A | |
| SCHEMBL24819926 | 0.90 | KCNH2 (0.47) | KCNH2VSIRPDCD1CD274CLK1 | |
| SCHEMBL30153009 | 0.89 | CBLB (0.36) | VSIRHTR3AMDM2CBLB | |
| SCHEMBL24818736 | 0.89 | CBLB (0.36) | VSIRHTR3AMDM2CBLB | |
| SCHEMBL30153084 | 0.88 | VSIR (0.40) | KCNH2VSIRPDCD1CD274CYP2D6 | |
| SCHEMBL24820155 | 0.88 | VSIR (0.40) | KCNH2VSIRPDCD1CD274CYP2D6 | |
| SCHEMBL30152568 | 0.87 | VSIR (0.40) | KCNH2VSIRPDCD1CD274CYP2D6 | |
| SCHEMBL24820273 | 0.87 | VSIR (0.40) | KCNH2VSIRPDCD1CD274CYP2D6 | |
| SCHEMBL24818952 | 0.87 | VSIR (0.41) | KCNH2VSIRPDCD1CD274CYP2D6 | |
| SCHEMBL30153006 | 0.87 | VSIR (0.41) | KCNH2VSIRPDCD1CD274CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |