SCHEMBL24820550

SCHEMBL24820550

CNC(=S)NNC(=O)c1ccccc1Br

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 1.00
GAA P10253 6/20 0.64
MEN1 O00255 2/20 0.64
KMT2A Q03164 2/20 0.64
RAB9A P51151 4/20 0.61
NPC1 O15118 1/20 0.61
SMN1; SMN2 Q16637 3/20 0.60
ALPL P05186 2/20 0.59
ALPI P09923 2/20 0.59
ALPG P10696 2/20 0.59
MAPT P10636 2/20 0.55
LMNA P02545 1/20 0.53
POLB P06746 1/20 0.53
HTT P42858 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
HPGD P15428 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29473289 0.83 ALDH1A1 (0.71) ALDH1A1GAAMEN1KMT2ARAB9A
SCHEMBL1346228 0.81 GAA (0.83) ALDH1A1GAAMEN1KMT2ARAB9A
SCHEMBL30825401 0.80 ALDH1A1 (0.67) ALDH1A1GAAMEN1KMT2ARAB9A
SCHEMBL8763632 0.80 ALDH1A1 (1.00) ALDH1A1GAAMEN1KMT2ARAB9A
SCHEMBL7724161 0.80 ALDH1A1 (0.67) ALDH1A1GAAMEN1KMT2ARAB9A
SCHEMBL1853517 0.80 ALDH1A1 (0.66) ALDH1A1GAAMEN1KMT2ARAB9A
SCHEMBL31286521 0.78 ALDH1A1 (0.64) ALDH1A1GAAMEN1KMT2ARAB9A
SCHEMBL31039282 0.78 ALDH1A1 (0.64) ALDH1A1GAAMEN1KMT2ARAB9A
SCHEMBL27085802 0.78 ALDH1A1 (0.64) ALDH1A1GAAMEN1KMT2ARAB9A
SCHEMBL27086121 0.78 ALDH1A1 (0.64) ALDH1A1GAAMEN1KMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4653436-A1 HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF GUANGZHOU YUFAN NANTU BIOTECHNOLOGIES CO., LTD (CN) 2025-11-26 EP disclosed
WO-2024153240-A1 HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF 珠海宇繁生物科技有限责任公司 2024-07-25 WO disclosed
CN-117858865-A CBL-B modulators and uses thereof 林伯士克莱奥公司 2024-04-09 CN disclosed
EP-4319756-A1 CBL-B MODULATORS AND USES THEREOF Nimbus Clio, Inc. (US) 2024-02-14 EP disclosed
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 WO disclosed
WO-2022217276-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-10-13 WO disclosed