Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CBLB | Q13191 | 3/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30152622 | 1.00 | GAA (0.40) | GAALMNACLK1SMN1; SMN2PTPN1 | |
| SCHEMBL30792073 | 0.87 | KDM4C (0.45) | GAALMNACLK1SMN1; SMN2KDM4C | |
| SCHEMBL24819927 | 0.87 | KDM4C (0.45) | GAALMNACLK1SMN1; SMN2KDM4C | |
| SCHEMBL24820650 | 0.87 | GAA (0.45) | GAALMNACLK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30792085 | 0.86 | PARP1 (0.43) | GAALMNACLK1SMN1; SMN2RAB9A | |
| SCHEMBL30153202 | 0.81 | LMNA (0.39) | GAALMNACLK1SMN1; SMN2MAPK1 | |
| SCHEMBL29920328 | 0.79 | GAA (0.39) | GAALMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL30792258 | 0.78 | ALDH1A1 (0.41) | GAALMNAALDH1A1BACE1KDM4E | |
| SCHEMBL24818953 | 0.77 | LMNA (0.43) | GAALMNAMAPK1 | |
| SCHEMBL27085837 | 0.77 | BRD4 (0.39) | GAALMNAMAPK1BACE1CBLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |